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Dph6 orthologs are found in nearly all sequenced Archaea and Eucarya, as expected from the distribution of the diphthamide modification.
The DUF71 family appears to have originated in the Archaea/Eucarya ancestor and to have been subsequently horizontally transferred to Bacteria.
The availability of over 3000 published genome sequences has enabled the use of comparative genomic approaches to drive the biological function discovery process.
Classically, one used to link gene with function by genetic or biochemical approaches, a lengthy process that often took years.
This observation suggests that some DUF71 members have different functions and probably participate in different biochemical pathways.].We have a database overflowing with the most gorgeous and generous women looking for mutually beneficial relationships with consenting adult males who don't mind getting spoiled by well off women.These women are not looking for gold diggers; they are looking for real men who can appreciate what a rich female lover can provide in exchange for time and attention.The 59 archaeal genomes analyzed all contained an EF-2 encoding gene.
Analysis of the distribution of Dph2 and Dph5 in Archaea showed that 58/59 genomes encoded these two proteins.In yeast, the first and last steps require additional proteins (Dph1, Dph3 and Dph7). (C) Ado-Pseudo-B12 structure and hydrolysis site by the bacterial Cbi Z enzyme (b Cbi Z).